3rd Degree Burns and Collagen



3rd Degree Burns and Collagen

    Collagen is a type of protein.which can have a profound influence on the outcome of 3rd Degree Burns, and deep 2nd degree burns
    Fibrous in nature, it connects and supports other bodily tissues, such as skin, bone, tendons, muscles, and cartilage. It also supports the internal organs and is even present in teeth. There are more than 25 types of collagens that naturally occur in the body.

    Skin collagen is formed mainly by two types of collagen, type I and type III.
    In mammals 25% of proteins in the body are formed by collagen.

    The most common Collagen is

  • Type I, present in skin, bones, ligaments, Then,

  • Type II is present in hyaline cartilage and intervertebral discs.

  • Type III occurs with type I in skin as reticular fibrils and also in smooth muscles.

  • Type IV is present in basal laminas.(thin base layers)

  • Type V can be found in basal laminas, dermis, tendons, bones and fibro-cartilage.

What has Collagen got to do with 3rd Degree Burns?

Hypertrophic scars are often the side effect of the healing process of deep bums and represent the greatest complication of the scarring process.
The main causes of hypertrophic burn scars are the over-production of collagen, and the absence of elastic fibres.

hypertrophic scar

Typical Hypertrophic Scar

In hypertrophic scars
, the lineal direction of the collagen mass is upset and the Fibres tend to be cross-linked, also, elastic fibres are less numerous or absent. These differences in the make-up of the hypertrophic scar may be the reason why the scars show an increased stretch resistance.

After deep burns, the dermis is not fully functional, if at all, and wounds that have been left to heal by themselves without skin grafting can take several months to heal, leaving a wrinkled, ridgy surface, known as an Hypertrophic Scar.

That is why split skin grafted surfaces mature 100% faster than such areas and are cosmetically much better. Regardless of the Meshing Settings.

Other Influences in Scar Formation

  1. Family History.

  2. First-aid treatment and therapy.

  3. Depth and extent of the Injury.

  4. Course of the whole treatment.

  5. Operative techniques.

  6. Rehabilitation during Hospitalisation

  7. Postoperative care.

  8. Scar compression after healing.

  9. Following care at home.

So! Does Collagen have any GOOD Points?

Oh!...Yes.
Collagen
is one of the main components of most of the current range of Artificial Skin products.

Artificial skin consists of a synthetic epidermis and a collagen-based dermis.

The artificial dermis is built with Collagen fibers arranged in a lattice that act as a template for the formation of new tissue. Fibroblasts, blood vessels, nerve fibers, and lymph vessels from surrounding healthy tissue grow into the Collagen lattice, which is eventually absorbed by the patient's system, then these cells and structures build a new dermis.

The synthetic epidermis, which acts as a temporary barrier during this process, is eventually peeled off and replaced with a split-thickness autograft or with an epidermis cultured in the laboratory from the patient's own skin cells.













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