Histamine in Burns

Histamine in Burns

Histamine is an organic compound found in animal tissues, in micro-organisms, and in some plants.

Its release stimulates muscles to contract, such as those in the gastrointestinal tract, uterus, and the bronchi. The finer blood vessels dilate and become more porous, causing the runny nose, watery eyes, and tissue swelling of various. In extreme cases it can lead to exaggerated responses from some  insect venoms, such as Bee Stings.

It also has a physiological role in the body's defenses against trauma by being activated by the inflammatory response. This results in increased blood flow to the damaged area to aid in tissue repair.

Bodily effects in the burns patient are due to huge amounts being released, especially when the burn injury is greater than 30% of Body Surface Area.

The most obvious effect noticed by the burns patient is the itching that starts as the skin grafts “take”, and start to heal. It is at this time that pressure garments would be fitted, and just as well, because the eternal itching would cause the patient to scratch until the newly healing areas were damaged, and even if he could sleep, he would be scratching in his sleep.
But even when wearing a pressure suit, a ruler or pencil inserted under the elasticised suit can bring Glorious Relief

This is when the Antihistamines are very welcome, and would be for many weeks.

Later, when the grafted areas have healed, the itching can continue because the Split Skin Graft provides no moisturising oils or sweat, and is very dry. I found that the application of Aloe Vera, and other ointments helped greatly.

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